iroyin

Da lori egungun aza-BODIPY, NIR1001 ṣafikun awọn ẹgbẹ ti n ṣetọrẹ elekitironi (fun apẹẹrẹ, 4-N, N-diphenylaminophenyl) ni awọn ipo 2,6, ti o n ṣe agbekalẹ D-π-D afọwọṣe1. Apẹrẹ yii dinku aafo HOMO-LUMO, yiyi oke gbigba ti o kọja 1000 nm ati imudara gbigbe idiyele intramolecular (ICT). Ni THF, NIR1001 ṣe afihan gbigba gbigba fọto meji ti o pọju (TPA) ti 37 GM, ilọsiwaju-meji lori awọn itọsẹ BODIPY ibile. Igbesi aye rẹ ti o ni itara-ipinlẹ ti 1.2 ps n jẹ ki awọn iyipada ti kii ṣe ipanilara daradara, ti o jẹ ki o dara fun itọju ailera photodynamic (PDT).

Awọn iṣiro DFT ṣe afihan pe ẹrọ gbigbe idiyele ti NIR1001 waye lati π-electron delocalization laarin awọn oluranlọwọ ati awọn ẹgbẹ olugba. Iyipada methoxy siwaju si imudara gbigba NIR ni ferese phototherapeutic (650-900 nm), imudarasi ifamọ1. Ti a fiwera si awọn awọ AF ti Yunifasiti Fudan, NIR1001 n ṣetọju iwuwo molikula kekere kan (<500 Da) pẹlu 40% fọtotability ti o ga julọ. Iyipada Carboxylation ṣe imudara omi solubility (cLogD=1.2), idinku adsorption ti kii ṣe pato ni awọn ọna ṣiṣe ti ibi

3. Biomedical Awọn ohun elo
Ni bioimaging, hCG-conjugated probe hCG-NIR1001 ṣe aṣeyọri aworan ti o ga ti awọn follicles ovarian ati micro-metastases labẹ 808 nm excitation. Pẹlu ijinle ilaluja ti 3 cm ni NIR-II, o ṣe ju awọn iwadii NIR-I lọ nipasẹ ilọpo mẹta, lakoko ti o dinku fifẹ abẹlẹ nipasẹ 60%. Ninu awoṣe ipalara kidirin asin, NIR1001 ṣe afihan 85% gbigbe-pato kidirin, wiwa ibajẹ ni igba mẹfa yiyara ju awọn iṣakoso macromolecular lọ.
Fun PDT, NIR1001 n ṣe agbekalẹ awọn eya atẹgun ifaseyin (ROS) ni 0.85 μmol/J labẹ itanna laser 1064 nm, ni imunadoko ni imunadoko apoptosis sẹẹli tumo. Liposome-encapsulated NIR1001 nanoparticles (NPs) kojọpọ awọn akoko 7.2 diẹ sii ninu awọn èèmọ ju dai ọfẹ lọ, dinku awọn ipa ibi-afẹde.
4. Iṣẹ-ṣiṣe ati Abojuto Ayika
Ninu awọn ohun elo ile-iṣẹ, NIR1001 ti ṣepọ sinu Juhang Technology's SupNIR-1000 analyzer fun yiyan eso, igbelewọn didara ẹran, ati sisẹ taba. Ṣiṣẹ ni iwọn 900-1700 nm, nigbakanna o ṣe iwọn akoonu suga, ọrinrin, ati awọn iṣẹku ipakokoropae laarin awọn aaya 30 pẹlu deede ± (50ppm + 5%). Ninu awọn sensọ CO2 adaṣe (ACDS-1001), NIR1001 jẹ ki ibojuwo akoko gidi pẹlu akoko idahun T90≤25s ati igbesi aye ọdun 15 kan.
Fun wiwa ayika, awọn iwadii iṣẹ NIR1001 ṣe awari awọn irin eru ninu omi. Ni pH 6.5-8.0, kikankikan fluorescence laini ni ibamu pẹlu ifọkansi Hg²⁺ (0.1-10 μM) pẹlu opin wiwa ti 0.05 μM, ti n ṣe awọn ọna awọ-awọ nipasẹ awọn aṣẹ titobi meji.
5. Imọ-ẹrọ Innovation ati Commercialization
Qingdao Topwell ohun elon gba iṣelọpọ lemọlemọfún lati gbejade NIR1001 ni 99.5% mimọ, pẹlu 50 kg/ipele agbara. Lilo awọn reactors microchannel, akoko isunmọ Knoevenagel dinku lati awọn wakati 12 si awọn iṣẹju 30, gige lilo agbara nipasẹ 60%. ISO 13485-ifọwọsi NIR1001 jara jẹ gaba lori ọja biomedical.